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No association between alcohol consumption and risk of atrial fibrillation: A two-sample Mendelian randomization study

Nutrition, Metabolism & Cardiovascular Diseases Apr 29, 2020

Jiang Q, Wang K, Shi J, et al. - Researchers assessed the causal link of alcohol consumption with the risk of atrial fibrillation (AF), via two-sample Mendelian randomization (MR) analysis. A genome-wide association study including 1,030,836 participants provided summary data on single nucleotide polymorphisms related to AF. Experts calculated the overall causal impacts by employing the fixed-effect and random-effect inverse-variance weighted method. In MR analysis, findings showed nonsignificant link of genetically predicted alcohol intake with AF risk. Overall, experts found no evidence of a causal link between alcohol consumption and AF.

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