Aksoy E, et al. - As complete blood count parameters provide novel inflammatory markers, namely neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), researchers investigated if any differences exist in these novel inflammatory markers according to exacerbation severity in patients with COPD in both eosinophilic and neutrophilic endotypes. They enrolled 10,592 patients in this retrospective cross-sectional study performed at a tertiary education hospital. Findings revealed different increases in the inflammatory markers in each COPD endotypes in COPD exacerbation. These findings seem to have implication for defining exacerbation endotypes, the severity of exacerbation, and treatment response during follow-up in COPD patients.