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Neonatal developmental and behavioral outcomes of immediate delivery vs expectant monitoring in mild hypertensive disorders of pregnancy: 5-year outcomes of the HYPITAT II trial

European Journal of Obstetrics & Gynecology and Reproductive Biology Nov 15, 2019

Zwertbroek EF, Zwertbroek J, Broekhuijsen K, et al. - Researchers examined how immediate delivery vs expectant monitoring influences neurodevelopmental and behavioral outcomes at 5 years of age in offspring of women with mild late preterm hypertensive disorders. In the HYPITAT-II trial, 704 women with a hypertensive disorder between 34 and 37 weeks of gestation were randomized to immediate delivery or expectant monitoring; children born during this trial were studied for this work. Five years after the original study, 148 women provided relevant data. An abnormal Ages and Stages Questionnaire score was reported in 22% (n = 14/65) of the children in the delivery group vs 21% (n = 13/62) in the expectant monitoring group. The analysis suggests no differences in developmental and behavioral outcomes at 5 years of age between a management policy of immediate delivery and expectant management in preterm hypertensive disorders. An increased risk of developmental delay at 2 years of age after immediate delivery was reported in the 2-year follow-up study, this risk, however, did not persist at 5 years of age.
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