Platt L, et al. - The aim of this systematic review and meta-analysis is to determine the impacts of needle syringe programmes (NSP) and opioid substitution therapy (OST), alone or in combination, for preventing acquisition of Hepatitis C virus (HCV) in people who inject drugs (PWID). The clinical data indicated that opioid substitution therapy lessens the risk of hepatitis C acquisition and is strengthened in combination with needle syringe programmes. There is weaker evidence for the impact of needle syringe programmes alone, although stronger evidence that high coverage is correlated with lessened risk in Europe.