Ganesh P, Heller T, Chione B, et al. - Although point-of-care (POC) technologies in resource-limited settings can circumvent challenges of centralized laboratory testing, improving clinical management, scaling up POC modalities has been inhibited by higher device costs and uncertain indications for use. In this study, researchers sought to address this gap via examining the feasibility and cost of targeted near-POC viral load (VL) testing in 2 large HIV clinics in Lilongwe, Malawi. Of 2,813 near-POC VL tests conducted, 1,511 (54%) tests were for patients for whom results and reason for the test were documented. Findings suggest the feasibility of targeted, near-POC VL testing and its consistent ability to allow prompt clinical action. Further reduction in the difference between the “all-in” cost of near-POC VL and centralized testing of $5.09 could be done in an optimized national program by combining targeted near-POC testing and centralized testing.