Khan AA, Al-Omary MS, Collins NJ, et al. - This study was attempted to evaluate the natural history and prognostic value of elevated left ventricular end-diastolic pressure (LVEDP) in patients with ST-segment elevation myocardial infarction (STEMI) after reperfusion with thrombolysis utilizing data from the Thrombolysis in Myocardial Infarction (TIMI) II study. A total of 3,339 patients were included in this study. Patients were assigned randomly to either an invasive (n = 1681) or a conservative (n = 1,658) strategy in the TIMI II study following thrombolysis. During hospitalization post-STEMI, LVEDP remains largely stable. The results showed that increased LVEDP is a predictor of death and heart failure hospitalization in STEMI patients undergoing successful thrombolysis.