Montenegro Sa F, et al. - In this retrospective longitudinal analysis, researchers studied differential characteristics, the main etiologies and prognostic outcomes of myocardial infarction (MI) with nonobstructive coronary arteries (MINOCA). Participants were 1,047 MI patients grouped based on the presence (MI and obstructive coronary artery disease [MICAD]) or absence (MINOCA) of any coronary stenosis of at least 50%. They found that, in the MINOCA group vs in the MICAD group, the total mortality rate was 8.8% vs 17.7%, respectively. Identified independent predictors of MINOCA included age, female sex, no previous tobacco use, atrial fibrillation, no previous AMI, and non-ST-segment elevation myocardial infarction diagnosis. Overall, MINOCA patients showed heterogeneity and had clinical characteristics that contrasted with classical cardiovascular risk factors. This entity represents a challenge, despite carrying lower mortality than MICAD. The often attributed low-risk classification for MINOCA may be flawed.