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Myocardial infarction risk stratification with a single measurement of high-sensitivity troponin I

Journal of the American College of Cardiology Jul 20, 2019

Sandoval Y, et al. - Researchers conducted this prospective, multicenter, observational study to investigate single measurement high-sensitivity cardiac troponin I (hs-cTnI) to identify patients at low and high risk for acute myocardial infarction (MI). The study sample consisted of patients with suspected acute MI enrolled across 29 U.S. sites with hs-cTnI measured using the Atellica IM TnIH and ADVIA Centaur TNIH (Siemens Healthineers) assays. Acute MI occurred in 12% of 2,212 patients. According to findings, recognizing the continuous connection between baseline hs-cTnI and risk of adverse events, using 2 Food and Drug Administration–cleared hs-cTnI assays, an optimized threshold of <5 ng/l safely identified nearly half of all patients as low risk at presentation, with hs-cTnI ≥120 ng/l identifying high-risk patients.
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