Myocardial fibrosis and the effect of primary prophylactic defibrillator implantation in patients with non-ischemic systolic heart failure—DANISH-MRI
American Heart Journal Jan 23, 2020
Elming MB, Hammer-Hansen S, Voges I, et al. - Given an increased risk of sudden cardiac death exists in patients with non-ischemic systolic heart failure, and the prediction of all-cause mortality by myocardial fibrosis, detected as late gadolinium enhancement (LGE) with cardiac magnetic resonance (CMR), has been demonstrated, so researchers performed this prospective observational sub-study of the Danish Study to Assess the Efficacy of ICDs in Patients with Nonischemic Systolic Heart Failure on Mortality (DANISH), to investigate whether patients with non-ischemic heart failure for whom ICD (implantable cardioverter-defibrillator) implantation would be beneficial can be identified by LGE. In this study, 252 patients underwent CMR. Using the full width/half maximum method, the quantification of LGE was done. All-cause mortality was the primary endpoint. Findings revealed that all-cause mortality was predicted by LGE in patients with non-ischemic systolic heart failure. Identification of a group of patients who experience longer survival as a result of receiving an ICD was not enabled by LGE in this cohort.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
-
Exclusive Write-ups & Webinars by KOLs
-
Daily Quiz by specialty
-
Paid Market Research Surveys
-
Case discussions, News & Journals' summaries