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Myocardial fibrosis and the effect of primary prophylactic defibrillator implantation in patients with non-ischemic systolic heart failure—DANISH-MRI

American Heart Journal Jan 23, 2020

Elming MB, Hammer-Hansen S, Voges I, et al. - Given an increased risk of sudden cardiac death exists in patients with non-ischemic systolic heart failure, and the prediction of all-cause mortality by myocardial fibrosis, detected as late gadolinium enhancement (LGE) with cardiac magnetic resonance (CMR), has been demonstrated, so researchers performed this prospective observational sub-study of the Danish Study to Assess the Efficacy of ICDs in Patients with Nonischemic Systolic Heart Failure on Mortality (DANISH), to investigate whether patients with non-ischemic heart failure for whom ICD (implantable cardioverter-defibrillator) implantation would be beneficial can be identified by LGE. In this study, 252 patients underwent CMR. Using the full width/half maximum method, the quantification of LGE was done. All-cause mortality was the primary endpoint. Findings revealed that all-cause mortality was predicted by LGE in patients with non-ischemic systolic heart failure. Identification of a group of patients who experience longer survival as a result of receiving an ICD was not enabled by LGE in this cohort.
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