Heng S, et al. - This study is performed to analyze whether multiple soluble TGF-β receptors are elevated in preeclampsia (PE) circulation and whether they synergistically block TGF-β signalling. Multiple soluble TGF-β receptors are present in pregnant circulation, all are majorly raised in early-onset PE and they synergistically inhibit TGF-β signalling. This information further recommends that decreasing soluble TGFβRIII rather than endoglin would be more effective to alleviate the inhibition of both TGF-β1 and TGF-β2 signalling in PE.