Schneider S, et al. - Among 738 young patients (aged 18 to 54-year) with ischaemic stroke, researchers determined short-and long-term mortality, clinical determinants, and causes of death. This hospital-based study was carried out in the two largest hospitals in Estonia from 2003 to 2012. In order to identify determinants of mortality, Logistic regression and Cox proportional hazard models with backwards stepwise analysis have been used. Data reported that 124 patients died during the 5-year follow-up. It was noted that cumulative mortality rates were 4.5% and 16.8%, respectively, at 30 days and 5 years. Findings revealed that the proportion of deaths from vascular causes was 87.9% at 1 month and 54.6% at 5 years. The results of this study suggested an independent association of 30-day mortality with severe stroke, with a National Institutes of Health Stroke Scale (NIHSS) score > 15, and poststroke infections. Poststroke infections, structural cardiac diseases, and moderate stroke severity with NIHSS score of 7-15 were the determinants of 5-year mortality. Such findings highlight the need for more successful prevention approaches in these groups of patients.