Bixler D, et al. - Data from chronic hepatitis B (CHB) patients seen in the Chronic Hepatitis Cohort Study (CHeCS) between 1 January 2006 and 31 December 2013 were analyzed to compare overall and cause-specific death rates and mean ages at death between CHeCS CHB decedents and U.S. decedents from the Multiple Cause of Death (MCOD) file. They identified 4389 CHB patients who were followed for a mean of 5.38 years. Among these, the death of 492 (11%) CHB patients was reported after a mean follow-up of 3.00 years. Decedents were more frequently older, more likely to be White (40.6%), African-American (27.1%), or male (74.2%) when compared to survivors. Decedents had higher tendency to have had cirrhosis (59.8%), diabetes (27.2%), alcohol abuse (17.7%), hepatocellular carcinoma (17.5%), or a liver transplant (5.7%); whereas survivors were more frequently Asian (48.8%). Death certificate data show underrepresentation of the true mortality from CHB.