Lapostolle F, et al. - Given a possible correlations of patient characteristics with the adverse influence of morphine on the action of oral adenosine diphosphate (ADP)-receptor blockers in ST-segment elevation myocardial infarction (STEMI) patients, researchers performed a retrospective analysis to assess if interaction between morphine use and pre-percutaneous coronary intervention (pre-PCI) ST-segment elevation resolution in STEMI patients in the ATLANTIC study (an international, multicenter, randomized study of treatment in the acute ambulance/hospital setting where STEMI patients received ticagrelor 180 mg ± morphine) was related with differences in patient characteristics and management. Outcomes revealed the association of morphine-treatment with increased glycoprotein IIb/IIIa inhibitor use, less pre-PCI Thrombolysis in Myocardial Infarction (TIMI) 3 flow, and more bleeding. For non-severe acute pain, morphine is advised to be used judiciously with the preferred non-opioid analgesics.