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Mitomycin C application after corneal cross-linking for keratoconus increases stromal haze

Journal of Refractive Surgery Feb 18, 2021

Awwad ST, Chacra LM, Helwe C, et al. - In this retrospective analysis, researchers sought to assess and compare corneal haze as determined by optical coherence tomography (OCT) after corneal cross-linking (CXL) for the treatment of mild to moderate keratoconus with or without mitomycin C (MMC) application. Participants in the study were 72 patients (87 eyes) with mild to moderate keratoconus. Findings revealed that anterior corneal reflectivity at 1 month and 1 year postoperatively was 14.79 ± 4.68 and 25.97 ± 15.01, and 13.88 ± 4.39 and 18.41 ± 9.25 for the CXL and CXL+MMC groups, respectively. The application of MMC following CXL raises corneal haze significantly. In order to assess the role of MMC in haze formation in such procedures, similar studies on simultaneous CXL and photorefractive keratectomy need to be performed.

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