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Missed study visits and subsequent HIV incidence among women in a predominantly sex worker cohort attending a dedicated clinic service in Kampala, Uganda

Journal of Acquired Immune Deficiency Syndromes Nov 04, 2019

Kasamba I, Nash N, Shahmanesh M, et al. - Researchers examined how the number of missed study visits (MSVs) within each episode of 2 consecutively attended visits affects subsequent HIV risk in a predominantly female sex workers (FSWs) cohort. Among women at high risk of HIV invited to attend an ongoing dedicated clinic offering a combination HIV prevention intervention in Kampala, Uganda, they scheduled study visits once every 3 months and included HIV-seronegative women with ≥ 1 follow-up visit from enrollment (between April 2008 and May 2017) to August 2017. Inclusion of 2,206 participants was done; among these, HIV incidence of 3.1/100 (170/5540) person-years was observed [95% confidence interval (CI): 2.6 to 3.5]. Observations revealed the association of missing study visits with increased subsequent HIV risk. Despite the role of several factors in this association, the finding infers the efficacy of targeted combination HIV prevention. However, they recommend monitoring, facilitating, and sustaining the exposure to targeted interventions in FSWs.
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