Rickels MR, et al. - In this four-session, randomized crossover trial, researchers ascertained if mini-dose glucagon (MDG) given subcutaneously before exercise could prevent subsequent glucose lowering as well as to compare the glycemic response to current approaches for mitigating exercise-associated hypoglycemia. For this analysis, 15 adults with type 1 diabetes treated with continuous subcutaneous insulin infusion were included who exercised fasting in the morning at ∼55% VO_2max for 45 min under conditions of no intervention (control), 50% basal insulin reduction, 40-g oral glucose tablets, or 150-μg subcutaneous glucagon (MDG). Results of this study suggested that MDG could be more efficient than insulin reduction for preventing exercise-induced hypoglycemia and could result in less postintervention hyperglycemia than ingestion of carbohydrate.