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MicroRNA-195 as a prognostic factor for cancer survival outcome in China: A meta-analysis

Cancer Management and Research Aug 28, 2019

Wang N, Cao Y, Ge X, et al. - Researchers carried out a meta-analysis of published studies to validate the prognostic value of microRNA-195 (miRNA-195 or miR-195, dysregulated in different kinds of cancers and plays a pivotal role in tumorigenesis) in human tumors. Until December 31, 2018, a detailed search on PubMed was conducted. Twelve studies involving 940 cancer patients were included in this meta-analysis to evaluate the prognostic value of miR-195 in different solid tumors. Investigators found that patients with high expression of miR-195 had favorable tumor-node-metastasis, lymph node metastasis and distant metastasis. High levels of miR-195 expression were closely associated with better overall survival at the same time. Findings suggested that elevated microRNA-195 can be a potential biomarker for predicting a favorable prognosis for different types of cancer in China. However, miR-195's exact functional role remains to be further studied through larger sample studies, which can validate and enhance miR-195's prognostic value in future and global cancer patients.
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