Xu X, et al. - The researchers intended to determine the association between metastasis-associated protein 1 (MTA1, a widely overexpressed gene in human cancers and is associated with advanced clinicopathological characteristics and survival in related diseases) and endometrial cancer (EC). In human EC tissues, the expression level of MTA1 was significantly greater, in contrast to normal endometrium. A positive correlation among MTA1 expression, lymph nodes metastasis and poor survival rate in EC was observed. Increased cell proliferation, migration and invasion abilities of EC cell lines Ishikawa, HEC-1B, and RL-952 was noted in experimentally overexpressed MTA1, while reduction of MTA1 were noticed hindering cell physiological behaviors. Further, it also reversed the negative effect of miR-30c which is a direct modulator of MTA1, on EC cells. Also, overexpression of MTA1 added to EC tumor growth, while the annihilation of MTA1 exhibited tumor growth inhibition. Hence, as a downstream target of miR-30c, MTA1 could support EC progression via AKT/mTOR/4E-BP1 pathway, which reflected the potential therapy target of MTA1 in EC.