Anyla M, et al. - The risk of metachronous cancers (MC) after primary colorectal cancer (CRC) in a Lynch syndrome (LS) population was determined. It was also determined if endoscopic surveillance should be more intensive. A greater risk of MC, especially CRCs, was found in patients with LS. The data indicated that the interval between surveillance colonoscopies following primary CRC should not exceed 18 months, especially in patients with a MSH2 mutation and a median time period of 24 months between colonoscopy and metachronous CRC.