Osman M, et al. - Via this meta-analysis of 19 eligible studies including 27,204 patients, researchers compared outcomes between patients with classical high gradient (HG) vs low gradient (LG) aortic stenosis (AS) who underwent transcatheter aortic valve implantation (TAVI). They performed a pairwise meta-analysis comparing 30-day mortality, mid-term all-cause and cardiovascular mortality at maximum follow-up between patients with HG and LG AS. They also undertook network meta-analysis to compare the same outcomes between the three distinct groups of AS comprising HG, paradoxical low-flow low-gradient (pLFLG) and low gradient with reduced ejection fraction (rEF-LG). Findings revealed better 30-day mortality, mid-term all-cause and cardiovascular mortality in patients with classical HG vs LG patients post-TAVI. Patients with rEF-LG and pLFLG demonstrated similar TAVI outcomes among patients with LG severe AS.