Barbarawi M, et al. - Researchers compared early vs delayed invasive management of non-ST-elevation acute coronary syndrome, focusing on the effectiveness and safety of both approaches. For this purpose, they analyzed the relevant randomized controlled trials (RCTs) identified from Pubmed/MEDLINE, Cochrane Library, and Embase. Major adverse cardiovascular events (MACE) was considered as the primary outcome. Cardiovascular mortality, all-cause mortality, myocardial infarction (MI), and bleeding events were considered as secondary outcomes. Overall 14 RCTs with 9,637 patients (mean age 65.4, 67% males) were included. A lower incidence of MACE and recurrent ischemia was observed in relation to an early invasive strategy vs delayed invasive strategy in these patients. The groups did not significantly differ in terms of all-cause mortality, cardiovascular mortality, MI, or bleeding events.