Strongman H, Gadd S, Matthews A, et al. - Via a population-based cohort study, researchers used large-scale electronic health records data from multiple linked UK databases to address the evidence gaps of risks of specific cardiovascular diseases in survivors of a wide range of cancers. A total of 126,120 individuals with a diagnosis of cancer who were followed up for 1 year and 630,144 matched controls were included. Venous thromboembolism risk was higher in survivors of 18 of 20 site-specific cancers vs controls. In patients with ten of 20 cancers, including hematological, esophageal, lung, kidney, and ovarian cancer, elevated risks of heart failure or cardiomyopathy were noted. For multiple cancers, including hematological malignancies, increased risks of arrhythmia, pericarditis, coronary artery disease, stroke, and valvular heart disease were also recognized. In patients without previous cardiovascular disease and in younger patients, HRs for heart failure or cardiomyopathy and venous thromboembolism were larger. Nonetheless, absolute excess risks were usually greater with advancing age. Heightened risks of these outcomes appeared to be most distinct in patients who had received chemotherapy. Survivors of most site-specific cancers had higher medium-term to long-term risk for one or more cardiovascular diseases vs that for the general population, with considerable disparities between cancer sites.