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Mechanisms of left atrial enlargement in obesity

The American Journal of Cardiology May 13, 2019

Aiad NN, et al. - In this study with 50 otherwise healthy obese subjects (BMI 37.2 ± 4.6 kg/m2, 50 ± 6 years), researchers investigated how left atrial (LA) size in obesity is impacted by ventricular (LV) remodeling. They also included 58 age and sex matched non-obese controls (BMI 26.2 ± 2.9 kg/m2, 52 ± 5 years) in this study. Echocardiography was performed to determine diastolic function, relative wall thickness (RWT) and LV mass. They used 3D-echocardiography to measure LA and LV volume. According to the findings, LA enlargement in obese patients generally occurs proportionately with LV enlargement and parallels eccentric LV remodeling. Increased RWT and mass were evident in relation to LA enlargement not in proportion with LV size. With the help of this unique signature, obese subjects with pathologic LA remodeling may be identified.

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