Wang J, et al. - Via this retrospective analysis, researchers focused on the link between mean platelet volume (MPV) and plaque vulnerability using optical coherence tomography (OCT) in patients (n=94) with non-ST-elevation acute coronary syndrome (ACS) (NSTE-ACS). Patients had undergone pre-intervention OCT examination. Overall plaque rupture, nonrupture with thin-cap fibroatheroma (TCFA), and nonrupture and non-TCFA cases were 17, 10, and 67, respectively. Independent risk factors of TCFA were diabetes and higher platelet distribution width (PDW), and independent determinants of plaque rupture were diabetes, higher body mass index, higher PDW, and higher MPV, as revealed in multivariate analyses. Findings revealed an independent association of higher MPV with a higher risk of plaque rupture as evidenced by OCT in patients with NSTE-ACS.