Hagberg KW, et al. - The risk of autism spectrum disorder (ASD) was assessed in the offspring of women who were exposed to antidepressants and/or had depression during pregnancy vs unexposed women. They used the UK Clinical Practice Research Datalink (CPRD) to identify the mother-baby pairs where the mother had ≥12 months of history prior to the delivery date and the child had ≥3 years of follow-up. Irrespective of antidepressant use, an increased risk of having a child with ASD was seen in women with depression during pregnancy. For treated depression, the relative risk (RR) of ASD was 1.72, and it was 1.50 for untreated depression vs those who were unexposed. In women who received antidepressants for other indications the RR was not elevated.