Mosser JF, et al. - For 52 countries across Africa from 2000 to 2016, researchers provided the first comprehensive annual estimates of diphtheria-pertussis-tetanus (DPT) coverage and dropout among children aged 12-23 months at local (5 × 5 km) and subnational (second administrative unit) spatial resolutions. This analysis was based on 183 surveys and included data from 881,268 children in 49 African countries. Clear national and sub-national inequalities in the coverage of DPT endure across the continent despite significant progress in Africa. Estimated third-dose (DPT3) coverage at the second administrative (ie, district) level varied by over 25% in 29 of 52 countries; only Morocco and Rwanda of 52 countries met the Global Vaccine Action Plan target of 80% DPT3 coverage or higher. Large areas in the Sahel, Somalia, eastern Ethiopia, and in Angola were found to have low DPT3 coverage. These outcomes can help identify areas of vulnerability in the low coverage and delivery of vaccines and can ultimately support more accurate resource targeting to improve African children's coverage of vaccines and health outcomes.