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Lung volume indices predict morbidity in smokers with preserved spirometry

Thorax Jul 26, 2018

Zeng S, et al. - In this study of the Veterans Affairs electronic health records, researchers investigated the significance of abnormal lung volumes that reflect air trapping in smokers with preserved spirometry (normal FEV1 to FVC ratio). For identified 7479 patients, who were at risk for COPD (ever smokers >40 years of age without restrictive lung disease) and had preserved spirometry and concomitant lung volume measurements, they analyzed subsequent health records for clinical diagnoses of COPD, healthcare utilisation, follow-up spirometry and mortality. They found that air trapping was common in smokers with preserved spirometry. Moreover, findings highlighted the role of air trapping as a predictor of adverse respiratory outcomes and progression to overt COPD.
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