Meignin V, et al. - Researchers sought to provide an accurate overview of post allogeneic hematopoietic stem cell transplantation (HSCT) noninfectious pulmonary complications (NIPCs) from a large number of lung biopsies. Reviewing 61 lung biopsies in patients with an NIPC, researchers found both bronchiolar (n=59) and alveolar/interstitial pathologies (n=27). Two types of bronchiolar lesions [bronchiolectasies (n=37) and fibrous and cellular lesions with luminal narrowing (n=43)] were identified. they also identified a wide spectrum of airway/interstitial pathologies [organizing pneumonia (OP, n=8), nonspecific interstitial pneumonia (NSIP, n=9), diffuse alveolar damage (DAD, n=6), lymphoid interstitial pneumonia (LIP, n=1) and pleuroparenchymal fibroelastosis (PPFE, n=2), as well as one instance of associated PPFE and NSIP]. In 41% of the reviewed cases (n=25), interstitial pathology was noted to be associated with bronchiolar lesions. Lung explants, from patients who underwent lung transplantation for post allogeneic HSCT end-stage respiratory insufficiency, displayed lung airway and interstitial inflammation. Findings thereby suggest encountering a wide spectrum of pathological lung lesions in post allogeneic HSCT NIPCs.