Lu X, et al. - In patients who underwent total knee replacement (TKR) or total hip replacement (THR) surgery, experts comprehensively compared the clinical outcomes of low-molecular-weight heparin (LMWH) with other anticoagulants. They searched Medline, Cochrane, EMBASE, and Google Scholar databases for eligible randomized controlled studies (RCTs) published before June 30, 2017. Findings suggested the probability of LMWH to have a higher risk of venous thromboembolism (VTE) and deep vein thrombosis (DVT) in comparison with factor Xa inhibitors, whereas LMWH may have a lower risk of major bleeding after THR or TKR, compared to direct thrombin inhibitors.