Kim K, et al. - In patients with type 2 diabetes (T2DM), researchers gauged the longitudinal association between diabetic retinal neurodegeneration and diabetic retinopathy (DR) progression by measuring macular ganglion cell-inner plexiform layer (mGCIPL) thickness. An independent risk factor for progression in early-stage DR was the progressive loss of mGCIPL. Significant predictive factors for DR progression were baseline mGCIPL thickness, mGCIPL thinning rate, CAN score, and conduction velocity of peripheral nerves, as seen in multivariate regression modeling.