Herraiz I, et al. - The purpose of this study is to describe, in singleton pregnancies complicated with early-onset fetal growth restriction (FGR), the progressing values of the sFlt-1/PlGF ratio in the weeks prior to delivery, differentiating cases with and without pre-eclampsia (PE). In this study, most early-onset FGR exhibits raised sFlt1/PlGF ratio from four weeks before delivery, and values are even higher if there is a concurrent PE. However, repeated measurements of the ratio have limited value, is only helpful to anticipate the requirement for imminent delivery in the FGR + PE group when values ≥ 655 are reached.