Packer M, et al. - Given that sirtuin-1 (SIRT1) and mammalian target of rapamycin complex 1 (mTORC1) represent two primary molecular regulators of lifespan, and that the balance of cellular priorities is shifted by both activation of SIRT1/PGC-1α (peroxisome proliferator-activated receptor-gamma coactivator) and inhibition of mTORC1 in a manner so as to encourage cardiomyocyte survival over growth, resulting in cardioprotective impacts in experimental models. The researcher noted that there exist experimental reports showing that most treatments that are clinically effective in the treatment of chronic heart failure with a reduced ejection fraction exert favourable impacts to activate SIRT1/PGC-1α/adenosine monophosphate-activated protein kinase and/or suppress Akt/mTORC1, and thereby, to encourage autophagic flux. Thus, experts suggest that the impairment of autophagy caused by derangements in longevity gene signalling possibly represent a seminal event in the evolution as well as advancement of cardiomyopathy.