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Long-term repeatability of optical coherence tomography angiography parameters in healthy eyes

Acta Ophthalmologica Sep 17, 2019

Lee MW, et al. - In this prospective, observational study involving 104 normal eyes, researchers examined the short-term and long-term repeatabilities of optical coherence tomography angiography (OCTA) parameters in normal people and identified the factors affecting such repeatability. They divided candidates into three groups based on differences in the signal strength (SS) of OCTA scans obtained at two visits at least 6 months apart: group 1, SS difference = 2; group 2, 1; group 3, 0. The coefficient of variation (CV) ranged from 3.89% to 8.10% and the intraclass correlation coefficient (ICC) ranged from 0.785 to 0.941 in short-term vessel density (VD) repeatability. The CV was 5.39–12.62% and the ICC was 0.598–0.867 in terms of long-term repeatability. Investigators found that OCTA parameters displayed excellent short-term and reasonable long-term repeatability in normal people. The variations in SSs between measurements influenced such repeatability, so doctors should question the reliability of OCTA parameters when there are 2 or more differences in SS even when the SS is high.
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