Yokoyama H, et al. - Researchers compared clinical features and outcomes of 94 nonagenarians with those of patients aged <90 years (n=673) among a sample of 767 consecutive patients who underwent transcatheter aortic valve implantation (TAVI) in three Japanese institutions and were prospectively enrolled in this study. Nonagenarians had significantly higher preoperative risk scores vs non-nonagenarians. A higher 30-day mortality and significantly higher major vascular complication were observed among nonagenarians vs in non-nonagenarians, but two groups had equivalent 3-year mortality. Associations of female sex, BMI and New York Heart Association (NYHA) class III/IV with all-cause mortality were evident even after adjustment for covariates. Overall, TAVI was safe and effective in nonagenarians, who demonstrated acceptable long-term results vs those for younger patients, although major vascular complication deserve careful attention.