Meshkin DH, Zolper EG, Chang K, et al. - A systematic review was performed to evaluate quantify long-term mortality rates after major lower extremity amputation in the chronic wound population available in the existing literature. Researchers carried out to search Ovid MEDLINE for publications that provided mortality data after major, nontraumatic, primary lower extremity amputations. They characterized lower extremity amputations as below and above the knee amputation. These data demonstrate the requirement for a paradigm shift in wound management and improved outcomes reporting. For recalcitrant ulcers, a focus on amputation prevention and care within a multidisciplinary team is critical.