Goloshchapov OV, Olekhnovich EI, Sidorenko SV, et al. - Researchers examined how fecal microbiota transplantation (FMT) affects the gut microbiota composition in healthy volunteers. Further, they sought to determine the long-term outcomes of FMT. A combined analysis of three healthy volunteers before and after capsule FMT was performed by assessing their general condition, adverse clinical effects, changes of basic laboratory parameters, and several immune markers. Evaluation of intestinal microbiota samples revealed a profound shift towards the donor microbiota taxonomic composition in all volunteers. This effect persisted in all the volunteers for almost ∼1 year of observation. Consistent transient changes of immune parameters were noted with suppression of T-cell cytotoxicity. FMT was identified as a relatively safe procedure to the recipients without long-term adverse events.