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Long-term impact of catheter ablation on arrhythmia burden in low-risk patients with paroxysmal atrial fibrillation: The CLOSE to CURE study

Heart Rhythm Dec 10, 2019

Duytschaever M, De Pooter J, Demolder A, et al. - Researchers investigated the longer-term influence of optimized catheter ablation (CA) on atrial tachyarrhythmia (ATA) burden by employing an insertable cardiac monitor (ICM) in this prospective, patient-controlled CLOSE to CURE study. Implantation of an ICM was done 65 days prior to CA in 105 patients with paroxysmal atrial fibrillation (AF). Contact force–guided pulmonary vein isolation targeting an intertag distance of ≤ 6 mm and a region-specific ablation index were included in CA. During the first and the second year following pulmonary vein isolation, a reduction in ATA burden from 2.68% at baseline to 0% and to 0%, respectively, was noted. They also found significant improvement in the quality of life across all scores. Findings revealed the effectiveness of CA in paroxysmal AF, with a major influence on ICM-identified ATA burden. Whereas a progressive decline in efficacy is indicated by conventional survival analysis, experts noted that burden reduction was maintained at a longer follow-up. ATA burden was suggested as a more optimal endpoint for evaluating ablation effectiveness.
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