Orvin K, Zekry SB, Morelli O, et al. - Researchers used data from a multicenter Israeli registry in order to evaluate 5-year structural and functional integrity results after trans-catheter aortic valve implantation (TAVI) with both self-expandable and balloon-expandable prosthetic valve devices. The study sample included 450 consecutive patients who had TAVI for severe symptomatic aortic stenosis; they were observed for a median duration of 5.6 years. Findings revealed a relatively low rate of valve deterioration or failure during long-term follow-up. Sustained hemodynamic performance, with average peak aortic valve gradient of 16.2 ± 8.9 mmHg and mean aortic valve gradient of 9.2 ± 6.6 mmHg, was shown by the prostheses in 184 patients (40.9%) who survived 5 years. Overall, 22 (12.3%) patients had late structural valve deterioration. Patients with small valves (23 mm) and high peak and mean transvalvular gradients at baseline more frequently developed bioprosthetic valve dysfunction.