Liao C, Zhang J, Jiang Y, et al. - Researchers conducted this Zhongshan Angle Closure Prevention Trial, a single-centre randomised controlled trial, to assess the impact of YAG laser peripheral iridotomy (LPI) on corneal endothelial cell density (ECD) and morphology in primary angle closure suspects (PACS) over 72 months. Patients with bilateral PACS received YAG LPI prophylactic treatment in one eye randomly, whereas the fellow eye served as control. The sample consisted of 875 participants [mean age was 59.3 ± 5.0 years and 83.5% female]. No significant correlation between age , gender, ocular biometrics, intraocular pressure and laser settings with change in endothelium was found in LPI-treated eyes, except for the time effect. The ECD declines over time primarily due to the impact of ageing. Over 72 months after treatment, YAG LPI does not appear to cause clinically significant corneal endothelial damage.