Gelpi M, Knudsen AD, Larsen KB, et al. - Researchers evaluated 848 people living with HIV (PLWH) from the Copenhagen Comorbidity in HIV Infection study for assessing if PLWH display long-lasting adipose tissue dysfunction after exposure to thymidine analogues (TA) and didanosine (ddI). For this purpose, they examined possible links between markers of adipose tissue dysfunction (adipose tissue density and adiponectin) and previous exposure to TA and/or ddI in the years after treatment discontinuation. According to prior exposure to TA and/or ddI, the participants were stratified (with, n = 451; without n = 397). Outcomes revealed that prior exposure to TA and/or ddI, even years after treatment discontinuation, was correlated with low adipose tissue density and impaired adiponectin production; this was observed independently of adipose tissue area. Findings infer long-lasting adverse effects of prior TA and ddI exposure on adipose tissue function and, subsequently, on cardiometabolic health in PLWH.