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Long‐term survival of patients with left ventricular noncompaction

Journal of the American Heart Association Jan 19, 2021

Vaidya VR, Lyle M, Miranda WR, et al. - Researchers focused on clinical as well as imaging features and risk factors for death in patients with left ventricular noncompaction (LVNC). This analysis involved 339 adults with LVNC. The presence of left ventricular ejection fraction < 50% was detected in 57% of patients and 48% of patients had isolated apical noncompaction. A median follow‐up of 6.3 years was performed during which deaths of 59 patients were reported. In multivariable Cox regression analysis, factors related to all‐cause mortality were: age, left ventricular ejection fraction <50%, and noncompaction extending from the apex to the mid or basal segments. Findings showed that patients with LVNC had reduced overall survival vs the anticipated survival of age‐ and gender‐matched US population. However, in patients with preserved left ventricular ejection fraction and isolated apical noncompaction, the observed survival rate was comparable with that of the general population.

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