Yan Y, Li S, Guo Y, et al. - In this investigation involving 877 adults (604 whites and 273 blacks; 355 males; mean age = 41.4 years at follow-up), researchers examined the dynamic changes in left ventricular (LV) mass and LV geometry over 6.4 years during midlife and ascertained if the adverse progression of LV geometric remodeling is affected by the cumulative burden of BMI and BP from childhood to adulthood. These adults had 5-15 examinations of BMI and blood pressure from childhood and 2 examinations of LV dimensions at baseline and follow-up 6.4 years apart during adulthood. After adjusting for age, race, gender, smoking, alcohol drinking, and baseline LV mass index, the authors identified association of the annual increase rate of LV mass index with all BMI measures, adult systolic blood pressure (SBP), and total AUC of SBP. They identified a significant association of all BMI and SBP measures (except childhood SBP) with increased risk of incident LV hypertrophy, with odds ratios of BMI vs SBP being significantly greater. Moreover, there was a significant and positive association of all BMI measures with incident eccentric and concentric LV hypertrophy.