Yan Y, Li S, Guo Y, et al. - The dynamic changes in left ventricular (LV) mass and LV geometry over 6.4 years during midlife were investigated and whether the cumulative burden of BMI and blood pressure from childhood to adulthood influence the adverse progression of LV geometric remodeling is examined. In this study, 877 adults (604 whites and 273 blacks; 355 males; mean age = 41.4 years at follow-up) were included; these adults had 5-15 examinations of BMI and blood pressure from childhood and 2 examinations of LV dimensions at baseline and follow-up 6.4 years apart during adulthood. After adjusting for age, race, gender, smoking, alcohol drinking, and baseline LV mass index, researchers identified association of the annual increase rate of LV mass index with all BMI measures, adult systolic blood pressure (SBP), and total AUC of SBP. They identified a significant association of all BMI and SBP measures (except childhood SBP) with increased risk of incident LV hypertrophy, with odds ratios of BMI vs SBP being significantly greater. Furthermore, there was significant and positive association of all BMI measures with incident eccentric and concentric LV hypertrophy.