Luo M, Zhang Q, Hu Y, et al. - Through data-independent acquisition (DIA) and enzyme-linked immunosorbent assays (ELISAs), researchers sought to determine differentially expressed proteins (DEPs) in plasma of patients with sepsis. In addition, convenient and accurate serum markers for determining the condition of septic patients were investigated. This study was performed including a total of 53 septic patients and 16 normal controls. They randomly selected 6 specimens from the normal group and 15 from the sepsis group for DIA-based quantitative proteomic analysis. Bioinformatics methods led to the identification of a total of 149 DEPs. The normal and sepsis groups showed significant differences in LGALS3BP levels. Significantly higher levels were evident in septic patients vs normal controls, and in addition, higher levels were observed in non-survivors vs survivors. Its great diagnostic efficacy and prognostic ability in sepsis is suggested by the ROC curves.