Burns JA, et al. - In this prospective analysis of 419 outpatients in a systematic heart failure with preserved ejection fraction (HFpEF) program, researchers tested the premise that anemia is more closely associated with volume status in HFpEF, and not markers of intrinsic myocardial dysfunction. All the included patients had their hemoglobin measured as well as comprehensive echocardiography, and in 311 patients, longitudinal, radial, and circumfrential strain were also measured. The link between anemia and echocardiographic/strain variables and adverse outcomes was determined using linear and Cox regression analyses, respectively. Findings revealed an association of anemia in HFpEF with markers of volume status, including echocardiographic E/A and E/e’ ratio and elevated right heart pressures such as right atrial pressure and pulmonary artery systolic pressure, and not intrinsic markers of myocardial dysfunction.