Osawa K, et al. - Researchers investigated if individuals with minimal coronary artery calcification (CAC) (Agatston scores of 1–10) have higher ischemic stroke or transient ischemic attack (TIA) frequencies, relative to those with no CAC. In these two groups, the relative prevalence of carotid atherosclerosis was determined, using participants from the Multi-Ethnic Study of Atherosclerosis (MESA) without previous cardiovascular events, including stroke, and with baseline CAC scores of 0–10. By carotid ultrasound, they detected carotid artery plaques and measured the intima-media thickness (IMT). A CAC score of 0–10 was found to be related to a low rate of ischemic stroke/TIA, negating the utility of a minimal CAC score as a predictive marker for ischemic stroke/TIA. However, a minimal CAC score may offer an early and asymptomatic sign of carotid artery disease.