Weidmann H, Bannasch JH, Waldeyer C, et al. - Researchers analyzed a large cohort of patients with coronary heart disease, to assess the prognostic worth of circulating soluble transferrin receptor levels (sTfR) levels among these patients. The disease cohort included 3,423 individuals who were suffering from angiographically documented coronary heart disease and who took part in the AtheroGene study. A combined endpoint of myocardial infarction and cardiovascular mortality and cardiovascular death alone were the two main outcomes that were considered. For future cardiovascular death and/or myocardial infarction, the estimated hazard ratio was 1.27 following adjustment for gender and age, as shown in Cox regression analyses for sTfR levels. Findings of this large cohort investigation revealed a strong link of sTfR levels with future myocardial infarction as well as cardiovascular mortality. A role for sTfR in secondary cardiovascular risk prediction was thus implicated.