Johnson RC, et al. - Researchers conducted whole-genome DNA sequencing at the National Institutes of Health (NIH) Clinical Center for the identification of a reservoir within the hospital's infrastructure on clinical isolates of multidrug-resistant Sphingomonas koreensis identified from 2006 to 2016. The examination revealed that two isolates of S. koreensis from the six patients identified in the 2016 cluster were unrelated but four isolates had a genetic similarity of more than 99.92% and were resistant to multiple antibiotic agents. Unique single-nucleotide variants identified in strains of S. koreensis has clarified the existence of a plumbing reservoir in a hospital. According to findings, S. koreensis is an opportunistic human pathogen that both persisted in the NIH Clinical Center infrastructure across time and space and caused health care–associated infections.