Khandhar SJ, Mehta M, Cilia L, et al. - In this prospective cohort study, researchers examined the invasive hemodynamics in patients with intermediate-risk pulmonary embolism (PE) and the change that occurs with catheter-directed thrombolysis (CDT). Participants in the study were 92 consecutive patients with intermediate-risk PE referred for CDT at two tertiary medical centers with Pulmonary Embolism Response Teams. To examine the link between clinical variables and low cardiac index (CI), linear regression analysis was conducted. Investigators found that 37 out of 92 had a CI less than 1.8 L min^–1 m^–2. According to findings, 40% of submassive PE patients had a depressed CI and CDT therapy resulted in hemodynamic improvements. Invasive hemodynamics may assist to better define and guide higher-risk patients.