Abdullatif AM, et al. - Experts conducted a single-center, open-label, interventional case series to ascertain the short-term safety of human recombinant decorin protein in preventing proliferative vitreoretinopathy (PVR) in perforating injuries. Ocular inflammation, electroretinogram (ERG) changes, and retinal layer integrity were assessed by optical coherence tomography (OCT). In patients with perforating injuries, authors did not detect any short-term safety concerns after a single intravitreal injection of decorin. They noted elevated decorin serum and vitreous levels following trauma, with higher and extended levels following intravitreal injection.